Medically reviewed by Jessica Pyhtila, PharmD, BCGP, BCPS.
Its scientific aliases are Tetramethyluric acid and Methylliberine, but don’t let those scare you away. The trademarked – and easier-to-pronounce – name is simply Dynamine™. It’s the somewhat-new-kid-on-the-block “stimulant” you’ve probably never heard of. Here we’ll examine its proposed properties, mechanisms, effects, and benefits.
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In a hurry? Here are the highlights:
- Dynamine™ is a patented methylliberine manufactured by Compound Solutions.
- It is found in nature in the kucha leaf.
- It is structurally similar to caffeine and theacrine, and like those, enhances mood, energy, focus, and motivation. It is believed to potentiate and synergize with caffeine.
- Dynamine™ has a faster onset, higher degree of effect, and shorter duration than its cousin theacrine.
- Dynamine™ is safe and well-tolerated at normal dosages.
- Dynamine™ is likely best suited for stacking with caffeine and/or theacrine.
Product Mentions:
– Dynamine™ capsules from the Nootropics Depot website.
– Dynamine™ powder from the Nootropics Depot website.
– DynaMAX – a caffeine/theanine/Dynamine combo from Nootropics Depot. You can find it on their website here.
– TeaCrine® capsules from the Nootropics Depot website.
– TeaCrine® powder from the Nootropics Depot website.
Contents
What is Dynamine?
Dynamine™ is a patented methylliberine manufactured by Compound Solutions1. Similar to theacrine/TeaCrine® (another of their patented creations), methylliberine/Dynamine™ is an isolated purine alkoloid found primarily in the kucha tea leaf, but not in black or green tea (Camellia sinsensis). It’s also found in smaller quantities in cocoa and yerba mate. Its effects are thought to be like that of a faster-acting, harder-hitting, shorter-duration TeaCrine®: enhanced mood, energy, focus, and motivation.
Methylliberine and its CNS-enhancing relatives caffeine, theacrine, and theobromine can all be found in the plant species Coffee robusta (not to be confused with your morning Coffee arabica)2.
Dynamine Benefits
- “Clean,” smooth energy without jitteriness typically associated with caffeine.
- Faster acting and harder hitting than theacrine.
- Relatively short half-life and duration of effect.
- Overall, enhanced mood, energy, focus, and motivation.
Dynamine’s Mechanism of Action — How Does it Work?
Like its cousin caffeine, it is thought that Dynamine™ exerts its effects by way of dopamine receptor activation and adenosine (fatigue signaler) inhibition. Specifically, though, Dynamine™ purportedly only allosterically modulates adenosine receptor activity (decreases sensitivity), whereas caffeine directly antagonizes (blocks) adenosine receptors. This property results in less tolerance buildup for methylliberine and theacrine compared to caffeine.
One study that has been published on Dynamine™ looked at it alongside theacrine (TeaCrine®) supplementation, and found no adverse effects on heart rate, heart rhythm, or blood pressure3. This is fitting, as neither Dynamine™ nor TeaCrine® are stimulants per se in the classical sense, suggesting you can potentially get caffeine-like benefits from them without the negative cardiovascular effects usually seen from moderate to high doses of caffeine4. This quality alone makes Dynamine™ and TeaCrine® part of a very rare group of bioactives that are strictly “neuro-activating,” possessing cognitive effects but not affecting heart rate or causing vasoconstriction as caffeine does. They could be considered pseudo-nootropic in that sense.
Methylliberine and theacrine are known as methylurates, whereas caffeine and theobromine are methylxanthines5,6. Without getting too scientific, Dynamine’s slightly different chemical structure means increased lipid solubility and easier blood-brain barrier (BBB) crossing compared to theacrine7.
Dynamine vs. Caffeine
Compared to caffeine, Dynamine® has:
- Less potential for tolerance buildup.
- Shorter half-life.
- No jitters.
- No effect on blood pressure or heart rate.
- No “crash,” habituation, or withdrawal issues usually seen with caffeine.
Dynamine vs. TeaCrine
The graph below is from Compound Solutions, the makers of Dynamine™ and TeaCrine®. It shows the proposed onset of action, degree of effects, and duration of effects of Dynamine™ compared to TeaCrine®8.
Note that Dynamine’s shorter half-life means its effects will likely be imperceptible after about 3 hours, making it a good caffeine alternative for the afternoons or evenings, unless you want to use rutaecarpine to eliminate caffeine faster. In terms of onset and duration, TeaCrine® has a much slower onset and much longer duration than both Dynamine™ and caffeine. Because of its slower onset, theacrine may a poor choice for a pre-workout supplement, unless you’re looking for sustained energy for the hours following your workout. Specifically, it takes about 90-120 minutes to “kick in.”
The peak degree of “EMF” (energy, mood, focus) enhancement is also likely higher for Dynamine™ than for TeaCrine®, albeit shorter-lived, as the graph above illustrates. Compound Solutions theorize that this is because Dynamine’s chemical structure allows it to readily cross the blood-brain barrier more quickly and more easily than TeaCrine®. Compound Solutions put together this neat graphic to show how Dynamine™ and TeaCrine® can work together, depending on your goals:
Watch the video below from Nootropics Depot to hear a representative from Compound Solutions discuss these properties of Dynamine9.
Click for Transcript
So some have asked about Dynamine, because it’s new as of April 2018. It’s just launched, so people want to know what it is and how it compares to TeaCrine. This is a common question. One, it’s also like TeaCrine, a purine alkaloid which again means it is similar to caffeine, but its mechanism is slightly different and makes the function very different. Instead of just being an adenosine inhibitor, it activates dopamine, and dopamine is your mood and motivation activator or neurotransmitter. So what is it? It’s really a compound that helps boost energy, mood, motivation, and focus. EMF. It’s perfect when you complement it with caffeine. Now if you’re looking at the onset of action, well, the onset, if you take it like a capsule or even a powder, is maybe about 25 minutes. You ingest it. 25 minutes later you can feel something. Now it feels even more intense when you combine it with caffeine. So it makes that 100 or 200 or 300mg of caffeine feel even more intense. Now how about TeaCrine? How does it relate? While the onset of action might be, let’s say, 25 minutes with Dynamine, it might be something like 45 minutes or even 60 minutes with TeaCrine. So caffeine hits first, then Dynamine, then TeaCrine. Caffeine lasts, let’s say, 2 hours. Dynamine lasts maybe 3 hours, and TeaCrine lasts maybe 5, 6 hours. So it’s a great full spectrum, sort of energy, mood, motivation, and focus.
About Dynamine’s Creators
Compound Solutions is one of the leaders in the sports nutrition and supplementation industry. Their efforts in advancing scientific research for maximizing human performance are admirable and well-known. In their words, they “believe science and research is paramount to human performance.” I can get behind that.
The specific co-inventors and researchers behind Dynamine™ are:
- Dr. Tim Ziegenfuss, PhD, FISSN, CSCS
- Shawn Wells, MPH, RD, CISSN, FISSN
- Dr. Hector L. Lopez, M.D., CSCS, FAAPMR, FISSN
Listen to Dr. Lopez and Dr. Shawn Arent talk about Dynamine™ in the video below from Compound Solutions10.
Click for Transcript
Lopez: In the TeaCrine & Dynamine study, we’re seeking to understand how adding a structurally, chemically structurally-related compound like Dynamine, the common name of which is methylliberine, and methylliberine is very structurally similar kind of like a chemical cousin to TeaCrine. Now, what we’re looking to do is we’re looking to see what implication adding a structurally-related compound like Dynamine to TeaCrine, what effect does that have on the same neurocognitive performance aspects that we’ve already seen advantages with just TeaCrine in isolation, or TeaCrine with caffeine in combination?
Arent: With the second study with TeaCrine, we’ve taken a little bit of a different approach. We’ve moved out of the sport athlete model into more of the tactical athlete model, so what we’re doing in this case is there’s been some interesting data that’s come out on the effects of mental fatigue. What we’re doing this time is we’ve actually set it up, so we’re going to use that same reaction time board we used in study one, but we’re going to use it for mental fatigue. In other words, they’re going to do a half hour of reaction time, fairly slow, but it’s enough that now you have to maintain sustained vigilance. Then what we’re going to do is we’re going to take them out of that. Now, imagine that you put a soldier, or a law enforcement officer into a live fire instant, right? So now they’ve come off, for example, sustained vigilance, watching a target, and now go. What we’re going to do is then we bring them out, and we’re going to have them doing physical response time, so we’re going to use our traser system to actually see what’s happened now after mental fatigue in terms of their movement capabilities. And then we’re going to have them do a simulated live fire exercise, where they’re actually going to use a handgun model that we’ve got for targeting, and they’ll actually be able to now … We’ll be able to track their accuracy, their response time, their ability to tactically reload. So what we’re trying to do is develop a model where we can see what this would do once they’re in the field, once they’ve had to now respond to a stress or respond to a demand, and look at how … In this case, we’re going to compare a placebo to caffeine, to caffeine, TeaCrine, and Dynamine as a combination to look at what happens there. That’s where it’s going to give us an idea of whether there is a synergistic effect, what might happen with this notion of sustained vigilance where you don’t have highs and lows. That’s really going to be the next question that we’re going to try to approach.
Lopez: The hypothesis is that adding Dynamine to a TeaCrine caffeine combination, or adding Dynamine to TeaCrine, will add additional efficacy in neurocognitive performance, in neuromotor and physical performance aspects, particularly in the early stages that you may not really see with TeaCrine alone.
Arent: Our hypothesis is that caffeine as a stimulant itself should improve overall performance, but the combination, because of the nature of how they overlap with each other and what we’re seeing for perhaps their ability to allow for a more improved accuracy response, should be even better.
I had actually been unknowingly using a few of CS’s ingredients – TeaCrine® and PeakO2® – in my supplement regimen for a while without knowing much about the company itself. It makes sense that Dynamine™ is yet another exciting science- and research-backed, results-oriented compound from these guys.
My Dynamine Review
The quicker onset of Dynamine™ is the first thing I noticed. Within 20 minutes or so, my brain was buzzing. Effects were indeed largely similar to theacrine; more on that later. Dynamine’s presence is subtle; it’s not a sudden, noticeable shift in energy and physical manifestation like you’d see with caffeine. It’s more of a clean, smooth focus, not unlike a 1:1 caffeine-with-theanine combination wherein theanine “smooths out” the caffeine.
There’s also definitely a synergistic effect with caffeine; I think the two together are greater than the sum of each individually, in terms of amplification of effects and earlier onset of action. Other anecdotal evidence reports this as well. Because of that fact, I would suggest not adding Dynamine™ to your usual caffeine dosage the first time you try it, especially if you’re a heavy caffeine consumer; use a lower caffeine dose or try Dynamine™ by itself first. Theoretically, methylliberine should potentiate other xanthines like theobromine and theophyline (found in cacao, tea, and yerba mate) as well.
Update March 2020: My above theorized synergism of Dynamine™ and caffeine has now been empirically confirmed. A recent study showed that Dynamine™ affects caffeine’s pharmacokinetics by extending its half-life and area under the curve (systemic exposure) “approximately two-fold,” and that co-administration with TeaCrine® increased caffeine’s half-life three-fold11. This is illustrated in the chart below:
The optimal protocol for Dynamine™ – and perhaps the whole purpose of the compound – seems to be using it in combination with TeaCrine® and/or caffeine, rather than Dynamine™ by itself, to achieve that aforementioned synergism and a smoother, sustained EMF enhancement. I would throw theanine in the mix as well; more on that below.
I would argue Dynamine’s effective amplifying of caffeine should allow you to get the same effect as usual from a lower dose of caffeine, essentially increasing alertness perhaps without hitting the threshold for the jitteriness and anxiety that accompanies higher caffeine doses. This would also allow you to avoid or lessen tolerance buildup, ultimately decreasing the potential for caffeine withdrawal symptoms later, and also decreasing the potential for or severity of the famous caffeine “crash.”
Throwing TeaCrine® in the mix should simply prolong/extend those effects and may eliminate that “crash” altogether. TeaCrine® also does not exhibit tolerance buildup seen with caffeine; Dynamine should be similar in that regard. Moreover, Dynamine’s lack of influence on the cardiovascular system consequently means less stress on the adrenals and comparatively smaller increases in stress hormones like cortisol and noradrenaline than what would be seen with caffeine.
Admittedly I’m not a huge fan of TeaCrine®, simply because of its extremely long half-life of about 20 hours. Unsurprisingly, I had trouble falling asleep at bedtime while trying it out. Dynamine™ solves this problem. Pharmacokinetically, it can be thought of as a shorter-lived, quicker-onset, harder-hitting TeaCrine®, though this hasn’t been scientifically confirmed yet. Compound Solutions are currently conducting trials and more research on Dynamine™ to empirically confirm the anecdotal reports.
I’m also curious to see how Dynamine plays with other acute EMF things like dopaminergics, cholinergics, tyrosine, racetams, etc.
Dynamine Studies
Update March 2020: Since this post was first written, several empirical human studies on Dynamine™ have been conducted.
One looked at 24 college students to see effects on heart rhythm (electrocardiogram; ECG), resting heart rate (RHR), blood pressure (BP), and psychometric parameters (PP). Participants were assigned randomly to one of the following groups:
- Low-dose Dynamine (100mg)
- High-dose Dynamine (150mg)
- Low-dose Dynamine with TeaCrine (100mg Dynamine + 50mg TeaCrine)
- High-dose Dynamine with TeaCrine (150mg Dynamine + 25mg TeaCrine)
- Placebo (125mg Maltodextrin).
After 4 weeks of continuous use (taken upon waking with a glass of water), researchers found no significant effects on heart rhythm, RHR, BP, or PP. There were no adverse effects12.
Is Dynamine Safe?
Dynamine™ is structurally similar to TeaCrine®, caffeine, and theobromine, which have been proven to be safe at normal dosages. Compound Solutions’ toxicological assessment of Dynamine™ showed it to be non-toxic. They’re currently investigating other attributes to hopefully attain GRAS (generally regarded as safe) status.
Update February 2020: Dynamine™ has achieved self-affirmed GRAS (generally regarded as safe) status, “after six years of research and development, five safety studies and more than $600,000 in safety data.”15 The GRAS dose has been set at 105mg, meaning it is also safe at 100x that dosage.
Third-party toxicological assessments published in October 2019 found “unequivocally negative results” for mutagenic, clastogenic, and genotoxic activity in mice, and a NOAEL (no-observed-adverse-effect-level) for females of 225 mg/kg body weight per day, the highest dose tested, and a NOAEL for males of 150 mg/kg bodyweight per day13.
Another recent study corroborated these findings, showing no adverse effects on cardiovascular function and blood biomarkers in humans, after 4 weeks of supplementation by 125 participants14.
Attaining GRAS may not sound like much, but its requirements are stringent, and its implications are far-reaching. This means Dynamine™ can now reach a much wider audience, as some major stores require their supplements to carry the GRAS designation. Think energy drinks, gaming supplements, nootropic blends, etc.
“We’ve never seen an ingredient with this level of sensory experience—and safety profile—all in one package,” said Matt Titlow, Compound Solutions’ CEO. “Dynamine™ will absolutely change the game in energy, gaming and biohacking formulas. Now that Dynamine™ is GRAS, the door is wide open for the largest brands in the world to give their consumers the best possible energy, mood and focus products without worrying about safety.”15
Jacob Fishback, Brand Developer and Product Formulator for Lief Labs added, “When an energy ingredient like Dynamine™ achieves GRAS status, we can formulate a product with longevity behind it and we won’t have to worry that it is going to hit the FDA’s chopping block at any given moment.”15
Dynamine Side Effects
Side effects from Dynamine™ seem to be extremely rare. I’ve seen a couple users complain of slight nausea and dizziness.
Dynamine Dosage
Most Dynamine™ supplement claims and anecdotal reports put the “sweet spot” in the 100-200mg dose range, taken 1-2 times per day. I’d be a little hesitant to take much more than that until more research comes out, but that’s just me erring on the side of caution. Some pre-workout supplement companies are already including Dynamine™ dosages in excess of 300mg.
Dynamine Half-Life
Dynamine’s half-life is thought to be around 2 hours, with effects tapering off and likely being imperceptible after the 3 hour mark. Onset of Dynamine™ happens around 20 minutes after ingestion. Peak concentration occurs around 45 minutes.
Dynamine Pre-Workout
Dynamine’s inherent properties make it a perfect ingredient to include in applications like pre-workout supplements, energy drinks, a morning EMF stack to get your day started as you would with coffee, or simply as a nootropic by itself in preparation for a specific physical or cognitive task. I expect to see Dynamine™ being included in a lot more supplement blends over the next couple years.
Dynamine™ becomes especially useful in a pre-workout setting if you’re working out in the evenings, due to its short half-life, so it won’t interrupt your sleep. Some pre-workout supplements that include Dynamine™ are:
- DVST8 from Inspired Nutraceuticals
- Sparta Nutrition Pre-Workout
- Embrace the Suck from Bare Performance Nutrition
Dynamine Coffee
MyProtein released an instant Colombian coffee product with Dynamine® in May 2020:
Dynamine Supplements
To run the “n=1” studies on myself when trying new compounds, I always think it’s imperative to buy and try an ingredient by itself instead of within a blended supplement. Like Compound Solutions, Nootropics Depot (10% off with email signup) is all about research, quality, and transparency. They’re basically the gold standard in the supplement industry. They have a proven track record of providing the highest-quality research-backed ingredients with verifiable third-party analytical testing. They also just happen to have great customer service and fast shipping. I get all my nootropics from them. For a while now, they’ve been the antidote to the issues that have plagued the supplement industry and given it a bad reputation – label inaccuracy, questionable purity and safety, and lack of efficacy. In short, make sure you’re buying from a trusted seller and make sure you know what you’re getting. Nootropics Depot has both a standalone Dynamine™ product and a recently-released Dynamine/caffeine/theanine blend called DynaMAX that people have been raving about.
We haven’t talked much about theanine in this post, but it’s another natural compound found in tea that is responsible for relaxation and anti-stress effects. I like to say it “smooths out” caffeine; I never consume caffeine without it now.
DynaMAX takes the guesswork out of dosing the 3 compounds individually in tandem. Nootropics Depot really did their homework on this one. It contains 3 types of caffeine to accomplish its goal of clean, sustained EMF: “normal” anhydrous caffeine (instant release), a patented delayed-release caffeine from ZümXR®, and a patented extended-release caffeine (also from ZümXR®). You can read more about the ingredients from ZümXR® here.
Specifically, the patented delivery systems from ZümXR® mean the DR caffeine from has an onset around the 70 minute mark, and the ER caffeine provides about a 5-hour sustained release profile for normal caffeine metabolizers16. Because of this, I’d recommend taking DynaMAX first thing in the morning upon waking so that it doesn’t interfere with sleep later in the evening. If you find it does, or if you end up needing a 2nd capsule later in the day, you can always use rutaecarpine to flush the caffeine from your system faster.
Don’t shy away from the seemingly small dose of caffeine in DynaMAX (150mg). Again, remember Dynamine™ augments and synergizes with caffeine such that you should need less caffeine than normal to achieve the same level of EMF enhancement. If you need to, you can take 1 capsule twice daily.
As intended and expected, DynaMAX provides clean, smooth, sustained energy, motivation, and focus (EMF) for the entire day with no crash. Check it out here. Note that Natrium Health is a sister company of Nootropics Depot with the same high standards of quality.
Dynamine Capsules
Again, you might want to try Dynamine™ by itself first or incorporate it into your existing coffee/caffeine regimen. You can find the ingredient by itself on the Nootropics Depot website here. Obviously you’ll get more bang for your buck with the 90-capsule supply, but when first trying it out I’d suggest getting the 30-capsule bottle, in case for some reason you don’t like it.
Dynamine Powder
For those wanting to add it to a drink or powder stack, Nootropics Depot offers Dynamine™ in powder form as well. Just be sure to use an accurate milligram scale when dosing powders (I like this one). Fair warning, I’ve heard the powder tastes awful; I haven’t tried it yet myself.
Other Dynamine Reviews
As an added bonus, watch the guys over at PricePlow talk about Dynamine™ in the videos below17. They also have a blog post on the compound here. They echo the same sentiments that I’ve laid out here – that it’s likely better suited to be stacked with caffeine and/or TeaCrine®18.
Click for Transcript
CJ: What’s going on guys? Look who it is. Look at this guy, man.
Mike: We are back. It’s Mike with PricePlow, here with Robert and CJ, and-
CJ: Hold on, hold on. They don’t know who Mike with PricePlow is.
Mike: What’s up? I’m Mike. I’m the Founder of PricePlow and these two guys have been taking over the channel while I have been dealing with family issues. We got a third one in the family now.
Mike: Anyway, the 2018 stimulant race is on. It looks like DMAA has been going away. A lot of brands are moving away from DMHA. Compound Solutions has something new for us. This is the same company that makes all sorts of different ingredients including TeaCrine.
Robert: Mm-hmm (affirmative).
Mike: Which is used in a lot of pre-workout and stimulant formulas.
CJ: Dude, and we did that raw taste of it. Remember that?
Mike: Ooh.
Robert: Gross.
Mike: They say this one tastes better. This is actually Dynamine and so, also known as what is it, methylliberine.
Robert: Methylliberine, yeah.
Mike: We spoke to Compound Solutions on the phone. We’re going to have a whole blog post about this ingredient as well as the whole 2018 stimulant race because there’s a lot of moving parts going on right now.
Robert: Right.
Mike: Basically, they said, “Hey, you guys should try 100mg. Just take it straight. See if you feel anything. You could also move up to 200mg.” These are 100mg per capsule in here. Then, also add it to a pre-workout such as one that doesn’t have DMAA, DMHA or even maybe TeaCrine or anything.
Robert: Yeah.
CJ: Are there any expectations so far? Have we got any anecdotal feedback from other people or anything y’all have heard that this stuff is good or what?
Robert: Well, according to Compound, it’s supposed to be a harder, faster acting TeaCrine. So, its half-life, you’re going to get that high for probably 15 to 20 minutes after you take it. It’ll come down 2 to 3 hours after you take it and that which is kind of really where TeaCrine picks up and takes you from there. Ideally, you might want to stack both of these in a pre-workout, if companies won’t start putting both of these in there. So we’ll see how that goes.
Mike: Yeah. So the issue with TeaCrine is it lasted too long for a lot of people. People, they want to feel stuff. They want it to hit them right away.
CJ: Yeah, yeah, yeah, yeah.
Mike: Apparently what this really is, is the same molecule but a couple of atoms have just been moved around.
Robert: Yeah. They flipped the methyl group around. Now, they’re like inbred cousins or something. Kind of like that.
CJ: All right. We’ve got the inbred cousins.
Mike: Inbred Dynamine, inbred cousins. The situation though is that it hits, I guess, through your blood brain barrier faster or-
CJ: Yeah.
Mike: At least more easily.
Robert: Right.
Mike: You’re going to feel that more is what we’re supposedly going to find out.
CJ: Okay.
Mike: We’re about to do-
CJ: We’re going to try this though on its own and being that we’re, I would say, we’re all three stim junkies though. You think we’re going to feel something with just this? I mean, what do you-
Robert: It’s a different compound, so maybe.
Mike: I don’t know. I don’t think I am. I need caffeine. I don’t know. We’ll see.
CJ: Let’s find out, yeah.
Mike: Yeah. Here is what we’re going to do. Do you have those water cups?
CJ: Yup. Let me go get ’em.
Mike: What mugs are these, man?
Robert: Ooh.
CJ: Oh, dude.
Robert: No. I was kidding. I had it. I had it.
CJ: All right. This is actually my good buddy G’s. Actually, a client of mine, he has a military clothing company here in Austin called Zero Foxtrot.
Mike: Nice.
CJ: They carry all kinds of stuff but he hooked us up with these mugs. So we’ve got some cool mugs today.
Mike: Boom. What’s his name?
CJ: G.
Mike: Thank you, G.
CJ: Well, it’s Guido. We call him G.
Mike: Oh, dude.
CJ: Yeah.
Mike: If your name’s Guido, you got to stick with Guido.
CJ: I feel like you should, but I think he feels too much like a mob boss or something. It’s super Italian.
Mike: Cool. All right, down the hatch. All right. It is 10:36 on that clock right now. We got a whole day of review set up.
Robert: Yup.
Mike: We’re going to come back. I was thinking we’d feel this in 45 minutes if we’re going to feel it at all.
Robert: At least, yeah.
Mike: I’m the bear on this one-
Robert: Right.
Mike: Thinking maybe not.
Robert: Mm-hmm (affirmative).
Mike: Then, eventually, we’ll do some stims. But we’re going to try to just not touch any caffeine right now and we’ll be back in a little bit. But this is your introduction to Dynamine. Stay tuned to the PricePlow blog because we will have more and we’ll be back when we start to feel something or just like an hour later.
Mike: All right, gentlemen, it’s been about 50 minutes since we took this. I’m not sure. Okay. I’m obviously very excited. This is my first time filming with you guys for quite a while. I’m crazy excited, but we’re having fun man, right now. There’s definitely. I definitely want more caffeine right now. I’m going to say this is not a caffeine replacement by any means, but there’s something going on that’s slightly better focused where I’m slightly more tuned into what’s going on a little bit. I like this a lot, but I don’t think solo is the application for me, at least.
CJ: Look, we got to have an honest transparent conversation about this, guys. Here at PricePlow, I think we like to get into the objectivity of supplements. It’s looking at the numbers, looking at the facts, giving you as much data as we can because at the end of the day, all these kind of subjective I feel this way and that way, the way I feel versus the way Mike feels versus Robert versus somebody down on the floor can be very different. I have a high stim tolerance and so do these guys. Just you guys hearing from us, sometimes it’s hard to translate. Personally, I’m with Mike. Exactly the same kind of response, but I will tell you, there are people that I work with on a daily basis that probably would feel this in a substantial way.
Mike: Oh, you might be right. Yeah. I got you. So far, I’m thinking I think this would be a good training stimulant with caffeine.
CJ: Right.
Mike: I fully agree. We’re going to have to try it again. There’s going to be a couple of studies that will give us a little bit of the objective information, but overall, just for my first dose, I will say that I like this a lot better than TeaCrine.
Robert: It’s faster acting than TeaCrine. I mean-
Mike: That’s why.
Robert: The enhanced mental clarity is there. Theacrine’s not going to kick in until at least 90 minutes. If you waited longer, then you would feel that.
Mike: Right. And by then, I forget.
CJ: A good way for us to look at things objectively with stimulants is what we do is we just, we literally watch Robert’s eyes, and as they dilate, like it took 30 minutes to get the dilation to full speed.
Mike: Alright we got to get our video going now. So yeah, overall, I’m excited about this ingredient. This is definitely a contender as a supporting ingredient for some of these pre-workouts that I think we’re going to see in 2018.
Robert: Yeah. Nothing’s ever going to replace caffeine, so don’t think any of these stimulants that you’re going to hear us talk about are going to replace caffeine ever. Everything works better with caffeine.
Mike: I think the bigger game is this. Alone or in combination with some other stuff, able to replace DMAA. That’s what really is kind of the holy grail of work out stimulants in my opinion.
CJ: I think it’s going to take a while for us to get there though. I think in reality, here’s the deal. This very well could be a really, really good ingredient. Just like DMHA, when we started to see DMHA, but then all of a sudden, we started to see people play with the dosage-
Mike: Right.
CJ: And play with it.
Mike: Right.
CJ: It’s going to start by just kind of being introduced and then we’re going to get stronger and stronger and mix differently. And who knows where it ends up?
Mike: And Compound Solutions did say that you could take 200mg solo.
Robert: Right.
Mike: And we only did 100mg. I’m thinking I would definitely, definitely feel that and maybe-
CJ: 300.
Mike: Who is this guy?
Robert: 500.
Mike: This is why we can’t have nice things, CJ. You keep ruining it for everyone.
Mike: Alright. So far, so good. I’m liking Dynamine. I’m liking it better than TeaCrine, but yeah, we don’t yet know enough but we’re going to… Yeah. You’re going to see a lot of products coming out with it.
Robert: Yeah.
Mike: So you have to stay tuned to the PricePlow blog because we will have some articles on this stuff. We’ll cite you the sources and show you what Compound Solutions is allowing us to leak out so far.
CJ: Yup.
Mike: Alright. Subscribe to the channel and you’re going to see more of this one for sure.
CJ: See you later, guys.
Mike: Yeah, just-
Robert: I got my capsule.
Mike: You got your own. You don’t want to touch the one out of my hand.
Robert: Well, I mean, I pulled it out from the first time.
Mike: I’ve washed my hands so much in the last few months.
They have a Part 2 video below too.
Update March 10, 2020: Apparently this video has been removed. You can still read its transcript below.
Click for Transcript
CJ: What’s going on, PricePlow Nation? This little baggy right here is not drugs; this is Dynamine.
Robert: Yeah.
CJ: All right, so y’all probably saw our video that we already posted where we tried our first one-off tab. It was 100mg, I think, of Dynamine. We didn’t do it with any caffeine. I think for the most part we were fasted but we just took the tab, wanted to see how it worked. We thought it was okay.
Robert: Yeah.
CJ: We were a little bit underwhelmed, I’d say.
Robert: Yeah, you get a little bit of a brain tickle from it. That’s about it.
CJ: A little bit of brain … A little bit of tickle. Mike wanted us to both try 200mg, so basically two tabs. He also wanted to stack it with caffeine and see how that was.
Robert: Right.
CJ: Personally, I actually did that literally the next day. I had an early morning class, like 6 AM. I was very much in a fasted state; nothing in my stomach. First thing I did … And I actually put it in a vlog … Took two of the Dynamine tabs and then I drank of those Cocaine Energy drinks, which was 280mg of caffeine. Nothing else, really, though.
Robert: Right.
CJ: I liked it. I felt like I actually was pretty dialed in and put me in a pretty good mood. So, for the most part, I was … It was no DMAA, but it was definitely … It was something different. It was more than just me having an energy drink, I can tell you that much.
Robert: Yeah, and I would agree with that. I’ve run it several times. I’ve done it with just an energy drink, just 200mg by itself, using a pre-workout that had 200mg of caffeine and 100mg of theacrine. I did it once with 100mg of Dynamine and with 200mg of Dynamine.
CJ: Yeah.
Robert: You do not get any kind of overly aggressive energy or super dialed focus like a DMAA or a DMHA or even an eria jarensis would. You mostly get … It’s a tighter, it’s a cleaner focus. And you do get that action, that onset of heightened focus a little bit faster than theacrine. I still don’t … It doesn’t have any kind of pop or punch to me. You get tight focus. You get clean focus.
CJ: Yeah.
Robert: But there’s nothing that jolts you like a caffeine would, saying hey-
CJ: Sure.
Robert: -I’m here. I’m present.
CJ: That’s the thing is like, honestly, I’m okay with that because that’s actually what I’m looking … I’m looking for more of a smoothing effect.
Robert: Right.
CJ: Look, I think caffeine is caffeine and I think that with the proper dose, we can kick you in the teeth with something else.
Robert: Yeah.
CJ: For me, that’s why I love DMAA. DMAA by itself, for most of you … Nobody really took it by itself.
Robert: Right.
CJ: But really, if you took a product like Off The Chain, as an example, that was moderate caffeine with DMAA-
Robert: Right.
CJ: -You’ll notice it wasn’t a kick in the teeth, either. It was a very … Just kind of euphoria.
Robert: Yes.
CJ: I love that. And that’s kinda what I was looking for and I think this is trying to provide that on a lesser extent. I’m curious to see what different dosing of this and once the companies start to get playful, I’m excited to see Compound Solutions get this out there on the market.
Robert: Right.
CJ: People start putting it in products and see what happens.
Robert: Yep.
CJ: Whether or not it’s going to be the next big thing, I don’t know. But maybe. I mean, I’m actually … I’m more impressed than what I thought. I will say that.
Robert: Yeah. You definitely … It’s faster acting than TeaCrine. That’s evident just from running it. I lean more on the higher dosing. I don’t think 100mg is enough for me.
CJ: No.
Robert: Even with caffeine. I think you need to verge on the 150 to 200.
CJ: Well, even for me with DMAA, 60 and 70mg was awesome.
Robert: Yeah.
CJ: But at 30, eh. It was like … You know what I mean?
Robert: Right.
CJ: All right, guys. That’s it. We’ll keep you up to date on what’s going on with Dynamine. Compound Solutions, always bringing us the cool shit. So, yeah. We’ll keep you guys up to date and hopefully we will start to see some kick-ass products being playful with this stuff. If you guys like our videos, do me a huge favor and pound that subscribe button and also give us one of these right here. That’s the thumbs up. Comments are also welcome. We try to respond to as many of them as we can. We’ll see you guys on the next video. Bye, guys.
References
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- 10.Compound Solutions. TeaCrine + Dynamine – New Research Study from Compound Solutions. YouTube. https://www.youtube.com/watch?v=nWA4zJiUVko. Published August 14, 2018. Accessed May 19, 2019.
- 11.Compound Solutions. Dynamine® [NEW CLINICAL TRIAL]: Researchers discovered that Dynamine® extends caffeine’s half-life and increased its area under the curve approximately two-fold. PRWeb. https://www.prweb.com/releases/dynamine_new_clinical_trial_researchers_discovered_that_dynamine_extends_caffeines_half_life_and_increased_its_area_under_the_curve_approximately_two_fold/prweb16941379.htm. Published February 28, 2020.
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- 14.VanDusseldorp TA, Stratton MT, Bailly AR, et al. Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults. Nutrients. February 2020:654. doi:10.3390/nu12030654
- 15.Compound Solutions. DynamineTM from Compound Solutions, Inc. Receives GRAS Affirmation. PRWeb. http://www.prweb.com/releases/dynamine_from_compound_solutions_inc_receives_gras_affirmation/prweb16389540.htm. Published July 8, 2019.
- 16.zümXR®, LLC. zümXR Ingredients. zümXR. http://www.zumxr.com/ingredients. Accessed May 19, 2019.
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- 18.PricePlow. 200mg Dynamine + Caffeine | Our Dynamine Review. YouTube. https://www.youtube.com/watch?v=AexkcOBCETk. Published February 8, 2018. Accessed May 19, 2019.
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My morning coffee is robusta or a robusta Arabia blend.
Dynamine is good stuff just don’t take it with yohimbine ….get chills and nasal congestion and jitters